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Can Kratom Cause Liver Damage?

Concerns about the long-term health effects of Kratom products have increased during the past decade. Some individuals use Mitragyna Speciosa as an alternative to prescription pain medicines like opioids, but minimal research has investigated its effects on the body. The U.S.A Food and Drug Administration has not approved Kratom's use for medicinal purposes.


Mitragyna speciosa can cause adverse reactions, particularly at higher doses. Some of them include psychosis, tremors, and seizures. There is a concern about safety when using Kratom products. If you have a particular medical condition or usually take prescription medicines, your risk of experiencing adverse reactions to Kratom is higher. You're not alone if you're concerned about Kratom's safety on vital body organs like the liver.


kratom powder in a spoon

Hepatotoxicity and liver damage are possible side effects of long-term Kratom use. Scientists have found a correlation between Kratom use and liver damage in a few individuals. Research, on the other hand, is limited. Fatigue, nausea, and dark urine are all signs of liver damage, and they usually appear 1 to 8 weeks after starting to take Kratom.


If you're worried about Kratom and your liver, rest easy. This post covers how to take Kratom safely and what to watch out for.


The liver's function


Regarding removing toxins from our bodies and reintroducing them into the bloodstream, the liver is a vital organ.


In addition to removing toxins, the liver plays a crucial part in our most basic metabolic processes.


When it comes to all metabolic activities in the body, the liver plays a pivotal role. The liver cells break down fats and create energy in fat metabolism." Furthermore, it serves a similar role in the metabolism of carbs and proteins, two other macronutrients required for a healthy diet (and lifestyle).


That's all I can say: the liver is critical. A malfunctioning liver can have a cascading effect on the rest of the body if it can't complete its detoxifying and metabolizing functions.


What Is the Liver's Role in Kratom's Action?


Around 12 alkaloids make up the majority of Kratom's active components. The liver must metabolize each of these alkaloids before they can be eliminated from the body via the kidneys).


Just about any drug or supplement will have the same effect.


The high abundance of alkaloids in Kratom sets it apart, putting an additional burden on the liver to digest them all.


Liver harm from Kratom is quite uncommon for people who have healthy livers because they easily metabolize the herb.


Kratom can cause liver damage in persons with a genetic flaw or those who have preexisting liver damage, sensitivity to Kratom, and those using known liver-toxic drugs or substances.

Mitragynine is the most prevalent alkaloid in Kratom. To break down this molecule, the CYP2D6 enzyme in the liver is required, and CYP3A4 and CYP2C9.


Users who have problems with this route or are taking drugs that likewise influence these enzymes are more likely to suffer liver damage.


What damages the liver?


The Cleveland Clinic says many different things might harm or damage the liver. However, dietary habits and substance abuse can also have a role. Environmental and genetic factors account for the majority of the variance in risk.



In terms of liver damage, alcohol is likely the most well-known substance to do so. On the other hand, many other popular substances might cause liver damage if taken excessively or improperly. These include:


Acetaminophen and other over-the-counter analgesics (Tylenol, others).

Most antifungals, antibiotics, arthritis, and steroid medications are available only by prescription.

Aloe vera and kava are two examples of common herbal supplements.


Moderation is vital as it is in most things in life. Doctors generally agree that even moderate consumption of alcohol is safe. "Moderate" is the most important word in this sentence.

Problems usually arise when moderation becomes excessive for the majority of people.


What you can do if you discover that your liver is infected


If you notice any liver damage symptoms, while using Kratom, immediately stop using it. If anything goes wrong, you can detect the worsening of your nausea or exhaustion before it gets out of hand.


It will be easier to deal with symptoms if you catch them early.

Get in touch with your doctor to talk about it. They may tell you to stop using Kratom or to reduce your dosage.


Additionally, a doctor can assist you in evaluating if your liver or any other organs have sustained any lasting harm. Never ignore symptoms like this. Far if you're already showing signs of liver damage, using Kratom could lead to even more significant health problems in the future.

Indeed, renal failure can result from liver injury.


You may be tempted to ignore any Kratom-related problems if the herb is helping you with your health difficulties. Unfortunately, not everyone can benefit from Kratom.


What's the Evidence?


Kratom's liver effects are best studied in a meta-analysis that was published in 2020.

In addition to the seven cases reported by the Drug-Induced Liver Injury Network, 25 cases found in FDA databases, and 27 cases found in internet user forums, this analysis looked at 26 case reports and abstracts.


According to the findings, although Kratom poses a risk of liver damage, most people who use it will show no evidence of liver damage.


According to research, symptoms of Kratom withdrawal can last anywhere from 7 to 21 days.

The harmful effects of Kratom on patients with severe liver dysfunction were the subject of another investigation [3]. DILI — Drug-Induced Liver Injury — was used to label these incidents. Only 8 of the 404 patients in the study had recently used Kratom.


Of the eight Kratom-related cases, the researchers determined that seven were the result of Kratom exposure. For this reason, Kratom intake throughout the 22 days preceding their symptoms was used as a factor. Jaundice-like symptoms, including itching and stomach pain, were observed in these patients.


As a result, six of the seven patients had to be admitted to the hospital for additional treatment. No one was hurt.


Kratom has been linked to rare occurrences of liver damage, but it's not known how much of that harm is caused by impurities in the plant matter that weren't originally part of the plant.


Final Thoughts


As with any substance, there's a chance that Kratom can cause liver damage. However, this effect is extremely rare and appears to primarily impact those with underlying health concerns or using other medications.


Even with chronic or repeated use of Kratom, most people do not experience any liver harm.

kratom is safe for the liver, safe

However, the data regarding its liver-damaging effects is scarce and ambiguous. Several variables to consider, such as the concurrent use of other medicines, make direct evidence difficult to come by.


An increase in infrequent adverse reactions due to particular physiological characteristics is now statistically more likely as the number of users grows rapidly.


Accordingly, it may be concluded that Kratom is generally safe when used in low dosages. In rare situations, its liver-damaging effects can cause symptoms similar to jaundice.

It's advisable not to combine Kratom with any other drugs. Before beginning Kratom use, a physician's advice is highly suggested in these situations.

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