Kratom and Your Pet – A University of Florida Study
Over the last couple of years, Kratom has been a very inconsistent and polarizing subject. On the one hand, there are Kratom users who have seen the health and psychological benefits that Kratom offers first-hand, and on the other hand are the federal institutions that are working tooth and nail to make sure that Kratom is not legalized and is, in fact, banned from the face of the earth.
This tag of war has been going on for some time now, but recently, it seems like one side, the former, is winning the contest. More and more people are beginning to understand the health benefits that come with Kratom. Even the social standing of the herbal extract is slowly changing.
However, the paradigm shift with regards to Kratom cannot take place without sufficient medical backing. Even though Kratom has been around for thousands of years, its panacea properties, though known, have not been articulated properly. Medical studies on Kratom are thus not only essential but also fundamental in making sure that its properties are understood.
To this effect, a huge step has been taken. It is a well-known fact that before medical products are approved and put into the market for human use, a series of rigorous yet necessary tests have to be carried out on them. The said tests are conducted on different animals, all of whom have genetic similarities to human beings. Thus, after the said test has been conducted on the animals, it becomes easier to understand how humans will react to the said substance.
Kratom, right now, is one step closer to full human clinical trials, and this is the best news for both Kratom users and advocates worldwide. After a series of tests was carried out on rodents, success was found, and it was cleared for the next stage, clinical research on Kratom's effects on dogs.
The dog clinical trials are conducted to predict, to a certain degree at least, the pharmacokinetics of the herbal extract. Pharmacokinetics, essentially, is the study of how drugs are absorbed, metabolized, distributed, and then excreted from the body. Since humans and dogs share about 85 percent of their DNA, the similarities in pharmacokinetics are not farfetched.
The University of Florida conducted the studies were conducted, and the findings were amazing; surprising to some but anticipated by others.
The University of Florida findings
The study took particular interest in the alkaloids present in Kratom, specifically, mitragynine. This is because mitragynine has shown, from previous studies, to have analgesic, anxiolytic, anti-inflammatory, antipyretic, antidiarrheal, antidepressant, and euphoric effects.
The study found that Kratom, when administered to dogs, binds to the opioid, dopamine, adenosine, alpha-adrenergic, and serotonin receptors in the body. Mitragynine shows a particular affinity to the opioid receptors in the brain. The study also found that another alkaloid prevalent in Kratom, 7-hydroxymitragynine, has an affinity to the same receptors.
The study was conducted two-fold; first, the dogs were given an oral dose of Kratom at 5 milligrams per kilogram of body weight, and the second, the dogs were given an intravenous dose of mitragynine at 0.1 milligrams per kilogram of body weight.
The results obtained were the first detailed pharmacokinetic reactions of mitragynine in non-rodent species. One of the biggest problems that come with using Kratom is that you have to find the dosage that works for you through trial and error. The results of this study go a long way in helping decide the base dosage for humans.
One of the main aspects that were studied was the bioavailability of Kratom. Bioavailability, essentially, is the amount of substance that is absorbed into the bloodstream after metabolism, and other processes that break down the compounds that are entering the body have taken place. Both 7-hydroxymitragynine and Mitragynine were found to have very high bioavailability, around 70 percent, which shows that once ingested, most of it goes straight into the bloodstream.
Clearance is another issue that was put under scrutiny. Clearance is a vital aspect of pharmacokinetics, as it examines how much of the substance the body can safely expel after it has been used. Determination of clearance of a medical substance is integral in accurately determining the dosage required when using it.
In the canine body, it was found that the alkaloids present in Kratom, Mitragynine, and 7-hydroxymitragynine, can be safely cleared in the body after use. This is a huge discovery, as it means that they cannot build up in the body to toxic levels that may be harmful. Additionally, it means that the human dosage recommendations can be derived from the findings.
Behavior and tolerance
The psychological effects of Kratom, which may result in temporary behavioral changes, were also studied. In the dogs, it was found that no major adverse changes were noted in the behavior of the dogs. Anxiolytic effects and mild sedation were the two main changes observed, and the said sedation lasted between two to four hours after the Kratom was administered orally, and one hour after it was administered in an intravenous manner.
Additionally, the stress-related frenetic signs were reduced; there was reduced barking, pacing, spinning, and jumping. A small minority showered excessive drooling and lip-licking, which is thought to be a result of the poor palatability of Kratom in the oral solution. Luckily though, for humans, there is a myriad of ways through which this palatability can be overcome.
What this all means
The study found that Kratom was well tolerated in the canines and that it did not have any significant, let alone adverse side effects that would cause or detract from its use.
If all these results were obtained when the human phase of the clinical trials is reached, we would be better placed in understanding the potential of Kratom as a therapeutic agent. This way, Kratom could be recommended and connected to patients that have a huge need for it.
Additionally, it would be possible for the Kratom industry to adopt practices that would result in the safe and standardized use of Kratom not only countrywide but also all over the world, such as third-party laboratory testing and the plethora of other safety precautions that can be used.
Testimonials from pet owners
Dogs are the most common pets in every household. Some dog owners have supported the use of Kratom on pets. Certain dog owners claim to have administered Kratom to their pets when they were in pain, and the herb alleviated the discomfort. Therefore, you can use Kratom as a pain reliever in animals.
Some pets also reach extreme stages of stress and Kratom can be beneficial in such situations by making the pets lively and cheerful. Some pet owners also claim that Kratom is useful for gaining pets that have arthritis. They claim that old pets tend to be more active after consuming Kratom.
The University of Florida study was one of a very limited number of studies that dealt with the effects of the alkaloids in Kratom on a species. Even though such studies are not conducted on humans, they are important, as they serve as a precursor and harbinger in determining the efficacy and efficiency of Kratom as a panacea for many common ailments.
Since the study determined the guidelines that can be used in mitragynine use in canines, they serve as a perfect starting point if the study moves to the human phase. Only time will tell how far we are from actually carrying out the studies on actual humans. However, this study is huge news to the Kratom community as it will only serve the betterment of Kratom worldwide.