What Kratom Studies Are Currently Going On?
Most Kratom manufacturers questioned the lack of Kratom studies in 2018. Clinical trials of Kratom could help more people to understanding of the product’s potential in offering therapeutic effects. According to the National Institutes of Health, clinical studies to determine the health effects of the natural product have not been conducted.
Is there any change since 2018?
The National Institute on Drug Abuse awarded a two-year, $3.5 million grant to a team of researchers from the University Of Florida College Of Pharmacy in December 2018. The grant aimed to boost research on Kratom’s main alkaloids, 7-hydroxymitragynine and mitragynine.
In addition, researchers from the University of Florida were successful in their research and were awarded an additional $3.4 million grant five months later in May 2019. What did they find out during their research? What information was published? Are we close to government- funded clinical trials of Kratom? This article is going to answer these questions in detail.
What you need to learn about the 2018 Kratom Grant
We will begin by looking at the first two-year Kratom grant of $3.5 million. Before the National Institute on Drug Abuse approved the grant, the no government agency had funded the studies of Kratom. What was in the Kratom grant?
In 2018 for starters, researchers from the University of Florida estimated that between 2 and 4 million people use Kratom across the United States. The researchers called the product “poorly understood” justifying the $3.5 million grant and the subsequent studies of Kratom. Most government agencies have an interest in the grant, including:
- The Food and Drug Administration (FDA)
- The National Institute of Drug Abuse (NIDA)
- The Drug Enforcement Agency (DEA)
- The National Institutes of Health (NIH)
With the funding, Kratom researchers expanded their teams to bring together expertise, experience, and speed up the research. Samples that took between 2 and 3 months to generate in the past now take only a week.
In addition, the grant allowed researchers from the University of Florida to come up with a schedule to study Kratom. The next step of Kratom studies involved identifying the pharmacology of the product’s chemicals. These chemicals are the most prominent alkaloids of Kratom, which include mitragynine and 7-hydroxymitragynine.
What did the Kratom studies unveil through the 2018 Grant?
- Researchers from the University of Florida determined where alkaloids go when one consumes Kratom. Also, they could tell how the alkaloids are broken down into metabolites after consumption.
- Scientists ran pharmacodynamics tests in living things using each alkaloid of Kratom. This means that researchers introduced separate concentrations of 7-hydroxymitragynine and mitragynine into live rats. The team of UF researchers traced how the alkaloids travelled and where they went inside the brain and what they did in the brain. The research proved that Kratom alkaloids bind to mu-opioid receptors in the brain.
- Also, the aim of the primary research is to change the natural substance in Kratom to highlight specific effects. However, it is not clear if the researchers completed these Kratom studies.
What did the 2019 Kratom grant do for the research?
Unfortunately, the two-year 2018 Kratom grant stopped approving clinical trials. The 2019 five-year $3.4 million Kratom grant did not agree to approve the human clinical trials. The grant built upon the University of Florida previous team of researchers. The first study concentrated on Kratom alkaloids individually, while the second Kratom studies focus on realistic context.
The University of Florida team of researchers will compare Kratom effects in its traditional form for the first time. The additional studies of Kratom examine the plant’s effect as fresh leaves and dried leaves. When you consume Kratom’s products, you not only ingest mitragynine, or 7-hydroxymitragynine but also a combination of the two alkaloids as well as other alkaloids present in the plant.
Studies done from the two research grants
Are there publishable Kratom articles from these two (NIDA) National Institute of Drug Abuse research grants? Yes, there is, but the research is still underway. However, the first breadcrumb of published research was first spotted on October 20th, 2020.
According to a controlled animal study on Kratom is 2020 done by a team of researchers from the University of Florida, Kratom offered pain-relieving effects.” Of course, most users of Kratom from various parts of the world have reported similar benefits for several decades. Fortunately, a scientific study validates these claims.
It does not stop there. Researchers from the University of Florida reported that the pain relieving benefits of Kratom originated from the interception of mu-opioid receptors. The 2018 research grant provided researchers from the University of Florida the tools to prove Kratom alkaloids binding with the mu-receptors. The more the University of Florida researchers receive federal funding for clinical trials on Kratom, the more the public learns about the benefits of this plant.
In the 2020 study, Kratom enthusiasts learned more about the safety profile of Kratom. According to a PH.D professor of medicinal chemistry, Dr. Chris McCurdy in the University of Florida College of pharmacy, Kratom is safe to consume in across the wide dosing range and average human equivalence dose without affecting respiration or coordination.
While we still do not have approved clinical trials, we are learning more about 7-hydroxymitragynine and mitragynine. We are also discovering differences between traditional Kratom and modern Kratom in powder form as well as the products safety profile.
The future of Kratom research
Kratom researchers have made decent strides in the last few years. With continued National Institute of Drug Abuse funding, researchers from the University of Florida can continue to discover more about Kratom and its alkaloids. In addition, researchers are dedicating their lives to researching about Kratom.
As most people say: the more research about Kratom, the more the public learns about its beneficial properties to health and wellness. Also, the more researchers spend time researching more about Kratom the higher the chances that the U.S government and the public will accept it. Currently, most people are misinformed about the plant. Misinformation increases the chances of Kratom swindles taking away the product from the market.
The future of Kratom research is very promising. The recent studies about Kratom have proved that continued research on the product is worth our financial support, time, and effort. Since the 2019 five-year Kratom grant is still active, most Kratom fans hope that they will learn more about this plant.